The main reason for the formation of gallstones is currently believed to be due to the cholesterol content in the bile exceeding the normal ratio of bile acids and phospholipids, resulting in cholesterol crystallization and precipitation, which is closely related to metabolic factors. In clinical practice, gallstones are mainly divided into cholesterol, bilirubin, and mixed stones. Establishing an ideal animal model of gallstones is an important means to study the pathogenesis and prevention of gallstones, but there is no unified standard method. In summary, the most common modeling methods currently include high-fat and high cholesterol diet induction or lithogenic feed induction.

Observation indicators

Serum TBIL DBIL、TBA、ALT、AST、Ca2+ 、TG、TC、HDL-c、LDL-c， Pathological examination of gallbladder and liver, etc.

Partial experimental diagram display